Depakote Sprinkle® capsules: Swallow total or sprinkle on to meals, including applesauce or pudding and consume quickly. Will not chew the sprinkle capsule or contents.

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The next adverse reactions are actually identified all through put up acceptance usage of Depakote. Because these reactions are noted voluntarily from a populace of uncertain size, It's not constantly doable to reliably estimate their frequency or create a causal connection to drug exposure.

There is a heightened hazard of valproate-induced acute liver failure and resultant deaths in individuals with hereditary neurometabolic syndromes due to DNA mutations from the mitochondrial DNA Polymerase γ (POLG) gene (e.g. Alpers Huttenlocher Syndrome). Depakote is contraindicated in clients known to own mitochondrial disorders due to POLG mutations and youngsters below two decades of age who're clinically suspected of getting a mitochondrial ailment [see CONTRAINDICATIONS].

While there won't be any efficacy facts that particularly deal with for a longer time-phrase antimanic remedy with Depakote, the protection of Depakote in extended-phrase use is supported by information from record assessments involving close to 360 people addressed with Depakote for larger than 3 months.

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7.2 Effects of Valproate on Other Medication Valproate has become located to become a weak inhibitor of some P450 isozymes, epoxide hydrase, and glucuronosyltransferases. The following list offers information about the possible for an affect of valproate co-administration about the pharmacokinetics or pharmacodynamics of many frequently prescribed prescription drugs. The listing is not really exhaustive, considering the fact that new interactions are consistently currently being documented.

Children under the age of two yrs are in a noticeably amplified risk of developing deadly hepatotoxicity, In particular Those people on various anticonvulsants, those with congenital metabolic disorders, those with significant seizure Ailments accompanied by mental retardation, and people with organic and natural brain disease.

These highlights do not include things like all the information needed to use Depakote safely and securely and successfully. See whole prescribing details for Depakote.

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Know the medicines you take. Keep an index of them and exhibit it to the healthcare provider and pharmacist every time you get a new drugs.

Getting folic acid supplements just before finding Expecting and during early pregnancy can reduced the prospect of having a child that has a neural tube defect. If you are taking Depakote during pregnancy for virtually any clinical situation, your child is in danger for having lower IQ and could be in danger for producing autism or awareness deficit/hyperactivity dysfunction.

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